转移性非间变性甲状腺癌的化疗：古斯塔夫-鲁西研究所的经验
Chemotherapy in metastatic nonanaplastic thyroid cancer: experience at the Institut Gustave-Roussy.
作者信息
Droz J P, Schlumberger M, Rougier P, Ghosn M, Gardet P, Parmentier C
机构信息
Department of Medicine, Institut Gustave-Roussy, Villejuif, France.
出版信息
Tumori. 1990 Oct 31;76(5):480-3. doi: 10.1177/030089169007600513.
Forty-nine patients with metastatic nonanaplastic thyroid carcinoma were treated over a 10-year period. Five successive chemotherapeutic protocols were used: a combination of doxorubicin, etoposide, 5-fluorouracil and cyclophosphamide; elliptinium acetate; doxorubicin; cisplatin; and the combination of doxorubicin and cisplatin. Results obtained with the different protocols were very disappointing, with only two objective responses (3%). Phase II trials with new chemotherapeutic agents are warranted in selected cases of nonanaplastic metastatic thyroid carcinoma.
在10年期间，对49例转移性非间变性甲状腺癌患者进行了治疗。使用了五种连续的化疗方案：阿霉素、依托泊苷、5-氟尿嘧啶和环磷酰胺联合使用；醋酸椭圆玫瑰树碱；阿霉素；顺铂；以及阿霉素和顺铂联合使用。不同方案获得的结果非常令人失望，只有两例客观缓解（3%）。对于非间变性转移性甲状腺癌的特定病例，有必要进行新化疗药物的II期试验。
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