Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Cornea. 2013 Mar;32(3):257-61. doi: 10.1097/ICO.0b013e31825240d7.
Recent data regarding the mid-peripheral portion of the removed corneal button in transplant surgery indicate histopathologically that keratoconus was present also in the peripheral portion of the button. The intent of this study was therefore to investigate if peripheral changes could also be detected clinically by measuring the central and peripheral corneal thickness of KC patients.
Corneal pachymetry was measured with the Visante optical coherence tomography and Orbscan II. Of 52 subjects, 26 were KC subjects and 26 were age- and sex-matched control subjects.
Corneal thickness, in KC patients, was significantly reduced in all areas compared with corneal thickness among controls with both the Visante optical coherence tomography and Orbscan II.
The results of the present study have provided clinical evidence that KC is a disease affecting a wider area of the cornea. Although the KC cornea shows the greatest change in thickness in the ectatic region, this attenuation declines toward the periphery. The presence of peripheral thinning indicated that KC may be a "pancorneal" pathology and not limited to the ectatic portion.
最近有关角膜移植术中切除角膜瓣周边部分的资料表明，角膜圆锥角膜在瓣的周边部分也存在组织病理学证据。因此，本研究的目的是通过测量 KC 患者的中央和周边角膜厚度来检测是否也可以通过临床方法检测到周边变化。
采用 Visante 光学相干断层扫描仪和 Orbscan II 测量角膜厚度。在 52 名受试者中，26 名为 KC 患者，26 名为年龄和性别匹配的对照组。
与对照组相比，KC 患者的角膜厚度在所有区域均显著降低，Visante 光学相干断层扫描仪和 Orbscan II 均如此。
本研究的结果提供了临床证据，表明 KC 是一种影响角膜更大区域的疾病。尽管 KC 角膜在扩张区域的厚度变化最大，但这种衰减会向周边逐渐减少。周边变薄的存在表明，KC 可能是一种“全角膜”病理学，而不仅仅局限于扩张部分。
