Noh Hye Kyung, Kwon Byung Su, Kim Yoon Hwa, Lee Nam Kyung, Choi Kyung Un, Suh Dong Soo, Lee Dong Hyung, Kim Ki Hyung
Department of Obstetrics and Gynecology, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Department of Radiology, Pusan National University School of Medicine, Busan, Korea.
Obstet Gynecol Sci. 2017 Nov;60(6):602-607. doi: 10.5468/ogs.2017.60.6.602. Epub 2017 Oct 31.
Strumal carcinoid tumor of the ovary is a rare subtype of ovarian carcinoid tumors; it is characterized by an intimate mixture of thyroid and carcinoid tissues. We present a case of a 64-year-old woman who presented with the chief complaint of persistent, severe constipation for over 5 years; she was later found to have an ovarian strumal carcinoid tumor. Computed tomography showed a well-defined solid mass measuring 6.4 cm at the right adnexa. The patient underwent right salpingo-oophorectomy and was histopathologically diagnosed as having a strumal carcinoid tumor. Immunohistochemical examination showed immunoreactivity for peptide YY (PYY), which exerts an inhibitory effect on the peristaltic actions of the distal intestine. After surgery, the patient's constipation resolved rapidly, suggesting a correlation between PYY producing ovarian carcinoid tumor and constipation. This is the first case report of PYY producing primary strumal carcinoid tumor of the ovary associated with persistent, severe constipation from Korea.
卵巢甲状腺样类癌肿瘤是卵巢类癌肿瘤的一种罕见亚型；其特征是甲状腺组织和类癌组织紧密混合。我们报告一例64岁女性，主要症状为持续严重便秘5年以上；后来发现她患有卵巢甲状腺样类癌肿瘤。计算机断层扫描显示右侧附件有一个边界清晰的实性肿块，大小为6.4厘米。患者接受了右侧输卵管卵巢切除术，组织病理学诊断为甲状腺样类癌肿瘤。免疫组织化学检查显示对肽YY（PYY）有免疫反应，肽YY对远端肠道的蠕动有抑制作用。手术后，患者的便秘迅速缓解，提示产生PYY的卵巢类癌肿瘤与便秘之间存在关联。这是韩国首例关于产生PYY的原发性卵巢甲状腺样类癌肿瘤与持续严重便秘相关的病例报告。
