Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Br J Dermatol. 2012 Sep;167(3):598-605. doi: 10.1111/j.1365-2133.2012.11037.x. Epub 2012 Jul 23.
Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09% to 22%. To our knowledge, incidence rates have not been quantified before.
In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
We identified 60,042 rosacea cases and 60,042 controls (61·5% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.
酒渣鼻是一种病因不明的慢性面部皮肤疾病。流行病学数据稀缺且存在争议，报告的患病率范围为 0.09%至 22%。据我们所知，之前尚未对发病率进行量化。
在这项观察性研究中，我们量化了英国确诊酒渣鼻的发病率，并描述了酒渣鼻患者的人口统计学特征和眼部症状的患病率。我们比较了酒渣鼻患者和对照组之间的生活方式因素，如吸烟和饮酒。
我们使用英国基于全科医生研究数据库，确定了 1995 年至 2009 年间患有新发酒渣鼻的患者，并将他们与无酒渣鼻的对照患者（1:1）相匹配。我们评估了所有有风险的患者的个人时间，并评估了按年龄、性别、诊断年份和地区分层的酒渣鼻发病率。
我们共识别出 60042 例酒渣鼻病例和 60042 例对照病例（61.5%为女性）。英国确诊酒渣鼻的总体发病率为每 1000 人年 1.65 例。约 80%的病例在 30 岁以后被诊断出酒渣鼻。在索引日期，约 20.8%的病例记录了眼部症状。我们观察到当前吸烟者患酒渣鼻的相对风险显著降低（比值比 0.64，95%置信区间 0.62-0.67）。饮酒与发病风险略有增加相关。
我们使用英国初级保健数据，通过大型的流行病学研究量化了在临床实践中确诊的酒渣鼻患者的发病率和特征。吸烟与患酒渣鼻的风险显著降低相关。
