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β-石竹烯，一种从圣经香膏（乳香黄连木）中分离得到的化合物，是一种选择性诱导肿瘤细胞凋亡的物质。

β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines.

机构信息

French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boqer Campus, Midreshet Ben Gurion 84990, Israel.

出版信息

Evid Based Complement Alternat Med. 2012;2012:872394. doi: 10.1155/2012/872394. Epub 2012 Apr 10.

DOI:10.1155/2012/872394
PMID:22567036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3332194/
Abstract

The biblical balm of Gilead (Commiphora gileadensis) was investigated in this study for anticancerous activity against tumor cell lines. The results obtained from ethanol-based extracts and from essential oils indicated that β-caryophyllene (trans-(1R,9S)-8-methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene) is a key component in essential oils extracted from the balm of Gilead. β-Caryophyllene can be found in spice blends, citrus flavors, soaps, detergents, creams, and lotions, as well as in a variety of food and beverage products, and it is known for its anti-inflammatory, local anaesthetic, and antifungal properties. It is also a potent cytotoxic compound over a wide range of cell lines. In the current paper, we found that Commiphora gileadensis stem extracts and essential oil have an antiproliferative proapoptotic effect against tumor cells and not against normal cells. β-caryophyllene caused a potent induction of apoptosis accompanied by DNA ladder and caspase-3 catalytic activity in tumor cell lines. In summary, we showed that C. gileadensis stems contain an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells.

摘要

本研究考察了基列乳香（Commiphora gileadensis）的抗癌活性，以评估其对肿瘤细胞系的作用。从基于乙醇的提取物和精油中获得的结果表明，β-石竹烯（反式-(1R,9S)-8-亚甲基-4,11,11-三甲基双环[7.2.0]十一碳-4-烯）是基列乳香精油中的关键成分。β-石竹烯存在于香料混合物、柑橘味、肥皂、清洁剂、乳膏和乳液中，以及各种食品和饮料产品中，因其具有抗炎、局部麻醉和抗真菌特性而广为人知。它还是一种在广泛的细胞系中具有强大细胞毒性的化合物。在本研究中，我们发现 Commiphora gileadensis 茎提取物和精油对肿瘤细胞具有抗增殖和促凋亡作用，而对正常细胞没有作用。β-石竹烯在肿瘤细胞系中可引起强烈的凋亡诱导，伴随 DNA 梯状和 caspase-3 催化活性。总之，我们表明 C. gileadensis 茎中含有一种凋亡诱导剂，它以选择性方式作用于肿瘤细胞系，而对正常细胞没有作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a957/3332194/53f2265d6838/ECAM2012-872394.012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a957/3332194/53f2265d6838/ECAM2012-872394.012.jpg

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