Gilat Yaron, Shoenfeld Yehuda, Kotler Moshe, Iancu Iulian
Brill Mental Health Community Center, Ramat Chen, Tel Aviv, Israel.
Isr J Psychiatry Relat Sci. 2011;48(4):275-9.
A series of epidemiological, clinical and laboratory findings suggest an autoimmune process in schizophrenia and include, among others, high titers of various autoantibodies in the sera of patients. Antiribosomal P antibody is known to exist in systemic lupus erythematosus (SLE) patients with a psychiatric presentation, including psychosis, rationalizing the examination of its existence in patients with schizophrenia.
Sera of 59 patients, 48 diagnosed with schizophrenia and 11 diagnosed with a schizoaffective disorder, were examined for the presence of antiribosomal P antibody titers using ELISA. The control group consisted of 94 healthy subjects with similar age and gender distribution.
Anti-ribosomal P antibody titers were below cut-off level in 58 patients and borderline in one patient, similar to the low titers of the control group.
Previous investigations have demonstrated high specificity for anti-ribosomal P antibody in SLE patients with psychosis. In view of the results of this study, however, anti-ribosomal P antibody is not a biological marker for schizophrenia.
一系列流行病学、临床和实验室研究结果提示精神分裂症存在自身免疫过程，其中包括患者血清中多种自身抗体的高滴度。已知抗核糖体P抗体存在于有精神症状（包括精神病性症状）的系统性红斑狼疮（SLE）患者中，这使得对精神分裂症患者体内该抗体的存在情况进行检测具有合理性。
采用酶联免疫吸附测定（ELISA）检测了59例患者的血清，其中48例诊断为精神分裂症，11例诊断为分裂情感性障碍。对照组由94名年龄和性别分布相似的健康受试者组成。
58例患者的抗核糖体P抗体滴度低于临界值，1例患者处于临界值，与对照组的低滴度相似。
既往研究已证实抗核糖体P抗体在有精神病性症状的SLE患者中具有高特异性。然而，基于本研究结果，抗核糖体P抗体并非精神分裂症的生物学标志物。
