类视黄醇：新型免疫调节剂和肿瘤抑制因子？
Retinoids: novel immunomodulators and tumour-suppressive agents?
机构信息
Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Bari, Italy.
出版信息
Br J Pharmacol. 2012 Oct;167(3):483-92. doi: 10.1111/j.1476-5381.2012.02031.x.
Abstract
Retinoids play important roles in the transcriptional activity of normal, degenerative and tumour cells. Retinoid analogues may be promising therapeutic agents for the treatment of immune disorders as different as type I diabetes and systemic lupus erythematosus. In addition, the use of retinoids in cancer treatment has progressed significantly in the last two decades; thus, numerous retinoid compounds have been synthesized and tested. In this paper, the actual or potential use of retinoids as immunomodulators or tumour-suppressive agents is discussed.
摘要
类视黄醇在正常、退行性和肿瘤细胞的转录活性中发挥重要作用。类视黄醇类似物可能是治疗 I 型糖尿病和系统性红斑狼疮等不同免疫疾病的有前途的治疗剂。此外，类视黄醇在癌症治疗中的应用在过去二十年中取得了显著进展；因此，已经合成和测试了许多类视黄醇化合物。本文讨论了类视黄醇作为免疫调节剂或肿瘤抑制剂的实际或潜在用途。
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