Grigorova T M, Stas T A, Kadagidze Z G, Kovaleva V L
Vopr Onkol. 1979;25(7):86-90.
By using DNCB delayed hypersensitivity test, the reaction of spontaneous rosette formation (RSRF) and the reaction of inhibition of leucocytes migration the authors examined 55 female patients with different forms of trophoblastic tumors of the uterus and 15 females following the removal of the mole without any signs of the disease concerned. Forty three patients showed a positive DNCB test, 93 of them were completely cured, a negative test was noted in 12 patients, only a 50% cure being observed. RSRF indicated the increased level of rosette-forming cells from 4,7--28% up to 10,3--73% in a successful treatment and its decrease down to 0--5% in the tumor progression, except 7 patients showing reduced RFC levels after the recovery. The reaction of leucocytes migration inhibition has revealed a considerable depression of leucocytes migration (MI--from 0.35 to 0.78) in 18 of 25 patients with manifestations of an acute tumor process (72%). In 7 cases no inhibition was noted, in 6--the treatment being insignificantly effective or time-consuming. In 21 (47.8%) of 27 patients without any signs of the affection there was no inhibitory effect. Leucocytes of healthy donors failed to respond to the tumor extract in either of 24 cases.
作者采用二硝基氯苯迟发型超敏反应试验、自发玫瑰花结形成反应（RSRF）和白细胞游走抑制反应，对55例患有不同类型子宫滋养层细胞瘤的女性患者以及15例切除葡萄胎后无相关疾病迹象的女性进行了检查。43例患者二硝基氯苯试验呈阳性，其中93例完全治愈；12例试验呈阴性，仅观察到50%的治愈率。成功治疗后，RSRF显示形成玫瑰花结细胞的水平从4.7% - 28%增至10.3% - 73%，而在肿瘤进展期则降至0 - 5%，但有7例患者康复后形成玫瑰花结细胞水平降低。白细胞游走抑制反应显示，25例有急性肿瘤过程表现的患者中，18例（72%）白细胞游走受到显著抑制（MI从0.35降至0.78）。7例未观察到抑制现象，6例治疗效果不显著或耗时较长。27例无任何病变迹象的患者中，21例（47.8%）未出现抑制作用。24例健康供体的白细胞对肿瘤提取物均无反应。
