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真菌感染免疫学的激动人心的发展。

Exciting developments in the immunology of fungal infections.

机构信息

Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

出版信息

Cell Host Microbe. 2012 May 17;11(5):422-4. doi: 10.1016/j.chom.2012.04.010.

DOI:10.1016/j.chom.2012.04.010
PMID:22607795
Abstract

The last decade has brought significant advances in our understanding of antifungal immunity, which offer hope for the development of novel immunotherapeutics. In this commentary, we provide a snapshot of the protective innate and adaptive components of antifungal immunity and highlight several recent topics of interest, placing in context the three associated reviews in this issue of Cell Host & Microbe.

摘要

过去十年,我们对真菌免疫的理解取得了重大进展,这为新型免疫治疗的发展带来了希望。在这篇评论中,我们提供了真菌免疫的保护性先天和适应性成分的简要概述,并重点介绍了几个最近的研究热点,为本期刊载的三篇相关综述提供了背景。

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1
Exciting developments in the immunology of fungal infections.真菌感染免疫学的激动人心的发展。
Cell Host Microbe. 2012 May 17;11(5):422-4. doi: 10.1016/j.chom.2012.04.010.
2
Adaptive immune responses to Candida albicans infection.针对白色念珠菌感染的适应性免疫反应。
Virulence. 2015;6(4):327-37. doi: 10.1080/21505594.2015.1004977. Epub 2015 Jan 21.
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Th17 cells in immunity to Candida albicans.辅助性 T 细胞 17 在对白念珠菌免疫中的作用。
Cell Host Microbe. 2012 May 17;11(5):425-35. doi: 10.1016/j.chom.2012.04.008.
4
Dendritic cells in antifungal immunity and vaccine design.树突状细胞在抗真菌免疫和疫苗设计中的作用。
Cell Host Microbe. 2012 May 17;11(5):436-46. doi: 10.1016/j.chom.2012.04.005.
5
Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.前沿:Nlrp10 对白色念珠菌的保护性抗真菌适应性免疫至关重要。
J Immunol. 2012 Nov 15;189(10):4713-7. doi: 10.4049/jimmunol.1201715. Epub 2012 Oct 15.
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Antibody immunity and invasive fungal infections.抗体免疫与侵袭性真菌感染
Infect Immun. 1995 Nov;63(11):4211-8. doi: 10.1128/iai.63.11.4211-4218.1995.
7
Host defence against disseminated Candida albicans infection and implications for antifungal immunotherapy.宿主对播散性白色念珠菌感染的防御及抗真菌免疫治疗的意义。
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Looking into Candida albicans infection, host response, and antifungal strategies.探究白色念珠菌感染、宿主反应及抗真菌策略。
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Expert Opin Biol Ther. 2017 Jul;17(7):861-870. doi: 10.1080/14712598.2017.1322576. Epub 2017 May 2.

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exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds.表现出异质和适应性细胞保护反应的抗真菌化合物。
Elife. 2023 Oct 27;12:e81406. doi: 10.7554/eLife.81406.
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Nanotechnology-Based Strategies to Combat Multidrug-Resistant Infections.基于纳米技术的抗多重耐药感染策略
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A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies.一种深度学习方法,用于捕捉白色念珠菌形态的本质。
Microbiol Spectr. 2022 Oct 26;10(5):e0147222. doi: 10.1128/spectrum.01472-22. Epub 2022 Aug 16.
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GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells.GIP:一个从原生动物到癌细胞的基因组不稳定性映射的开源计算管道。
Nucleic Acids Res. 2022 Apr 8;50(6):e36. doi: 10.1093/nar/gkab1237.
6
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs.可扩展和可逆的拷贝数扩增驱动快速适应抗真菌药物。
Elife. 2020 Jul 20;9:e58349. doi: 10.7554/eLife.58349.
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Genome plasticity in is driven by long repeat sequences.是由长重复序列驱动的基因组可塑性。
Elife. 2019 Jun 7;8:e45954. doi: 10.7554/eLife.45954.
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IL-17 in Renal Immunity and Autoimmunity.白细胞介素-17 在肾脏免疫和自身免疫中的作用。
J Immunol. 2018 Dec 1;201(11):3153-3159. doi: 10.4049/jimmunol.1801042.
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Unexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection.意想不到的 IL-17 受体信号在防御系统性白念珠菌感染中的肾脏局限性作用。
JCI Insight. 2018 May 3;3(9):98241. doi: 10.1172/jci.insight.98241.
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The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney.激肽释放酶-激肽系统:白细胞介素-17驱动的肾脏抗念珠菌免疫的新型介质
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