Department of Agriculture and Bioscience, Hirosaki University, 3-Bunkyo-cho, Hirosaki 036-8561, Japan.
Bioorg Med Chem. 2012 Jun 15;20(12):3793-8. doi: 10.1016/j.bmc.2012.04.040. Epub 2012 Apr 27.
Plipastatin A1 and fengycin IX were experimentally proven to be identical compounds, while these had been considered as diastereomers due to the permutation of the enantiomeric pair of Tyr in most papers. The (1)H NMR spectrum changed to become quite similar to that of plipastatin A1, when the sample which provided resembled spectrum of fengycin IX was treated with KOAc followed by LH-20 gel filtration. Our structural investigations disclosed that the structures of these molecules should be settled into that of plipastatin A1 by Umezawa (L-Tyr4 and D-Tyr10).
普瑞巴林 A1 和丰加霉素 IX 经实验证明为同一化合物，而由于大多数论文中 Tyr 对映体的排列，这些化合物被认为是差向异构体。当用 KOAc 处理并通过 LH-20 凝胶过滤处理类似于丰加霉素 IX 谱的样品时，（1）H NMR 谱变得与普瑞巴林 A1 的谱非常相似。我们的结构研究表明，这些分子的结构应该通过梅泽滨（L-Tyr4 和 D-Tyr10）被确定为普瑞巴林 A1。
