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丰原素 A 类似物，具有增强的化学稳定性和抗真菌特性。

Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties.

机构信息

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom.

School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.

出版信息

Org Lett. 2021 Jun 18;23(12):4672-4676. doi: 10.1021/acs.orglett.1c01387. Epub 2021 Jun 2.

DOI:10.1021/acs.orglett.1c01387
PMID:34077216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8289291/
Abstract

Fengycins are cyclic lipo-depsipeptides produced by that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity.

摘要

丰余菌素是由 产生的环状脂肽，具有很强的抗真菌特性，但化学性质不稳定。这种不稳定性意味着没有任何丰余菌素的全合成被发表。在这里，我们报告了丰余菌素 A 类似物的合成，这些类似物在碱性和酸性条件下都表现出增强的抗真菌特性和化学稳定性。所制备的类似物还表明，丰余菌素的核心结构可以被修饰和简化，而不会失去抗真菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/e0506318444f/ol1c01387_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/29dad36118f7/ol1c01387_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/4d6e2af0c2bb/ol1c01387_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/2ea4a207a2ab/ol1c01387_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/e0506318444f/ol1c01387_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/29dad36118f7/ol1c01387_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/4d6e2af0c2bb/ol1c01387_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/2ea4a207a2ab/ol1c01387_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/8289291/e0506318444f/ol1c01387_0004.jpg

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