Lozano Herrero Jesús, Muñoz Bertrán Eduardo, Ortega González Isabel, Gómez Espín Rosa, López Espín María Isabel
Servicio de Medicina Interna, Hospital Morales Meseguer, Murcia, España.
Gastroenterol Hepatol. 2012 Dec;35(10):704-7. doi: 10.1016/j.gastrohep.2012.03.008. Epub 2012 May 18.
Wilson's Disease (WD) is an autosomal recessive disorder of copper metabolism resulting in a pathological accumulation of this metal, initially in the liver and later in other organs, mainly brain. Treatment with copper chelating agents and zinc salts results in a depletion of copper deposits and prevents or reverses the clinical manifestations. Copper deficiency may cause haematological and neurological changes, the latter principally being polyneuropathy and myelopathy. We report a patient with WD who developed a myelopathy associated with a deficiency of copper following prolonged treatment with D-penicillamine and zinc salts.
威尔逊病（WD）是一种常染色体隐性铜代谢紊乱疾病，会导致这种金属在体内病理性蓄积，最初蓄积于肝脏，随后累及其他器官，主要是脑。使用铜螯合剂和锌盐进行治疗可使铜沉积物减少，并预防或逆转临床表现。铜缺乏可能会引起血液学和神经学变化，后者主要表现为多发性神经病和脊髓病。我们报告了1例WD患者，该患者在长期使用D-青霉胺和锌盐治疗后发生了与铜缺乏相关的脊髓病。
