scopararanes C-G：海洋沉积物来源真菌 Eutypella scoparia FS26 产生的新含氧松香烷二萜
Scopararanes C-G: new oxygenated pimarane diterpenes from the marine sediment-derived fungus Eutypella scoparia FS26.
机构信息
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China.
College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
出版信息
Mar Drugs. 2012 Mar;10(3):539-550. doi: 10.3390/md10030539. Epub 2012 Feb 27.
Five new oxygenated pimarane diterpenes, named scopararanes C-G (1-5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1-5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1-5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.
从南海海洋沉积物来源的真菌 Eutypella scoparia FS26 的培养物中分离得到五个新的含氧松烷二萜，命名为 scopararanes C-G（1-5）。这些化合物的结构是基于广泛的光谱分析确定的。通过 CD 光谱分析和与文献数据的比较，确定了化合物 1-5 的绝对构型。所有分离得到的化合物（1-5）均通过 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基-2H-四唑溴盐（MTT）法对 MCF-7、NCI-H460 和 SF-268 肿瘤细胞系进行了细胞毒性活性评价。
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