Nakagawa M, Shimamoto K, Matsuda K, Saitoh S, Nakagawa H, Ura N, Iimura O
Second Department of Internal Medicine, Sapporo Medical College, Japan.
Am J Hypertens. 1990 Nov;3(11):873-5. doi: 10.1093/ajh/3.11.873.
Urinary immunoreactive endogenous digitalis-like substance (EDLS) excretion was studied in gradually reduced renal mass rats (RRM). Urinary EDLS increased immediately after the start of 1% NaCl ingestion, then it returned to the basal level 2 weeks later. Both urinary sodium excretion and urinary EDLS were significantly higher in 3/6 and 4/6 RRM than in control until 2 weeks after starting 1% NaCl. However, there was no difference in blood pressure between the groups. Transient EDLS increase may play an important role in maintaining sodium and water homeostasis, but its transient increase apparently does not contribute to blood pressure elevation.
对肾质量逐渐减少的大鼠（RRM）的尿免疫反应性内源性洋地黄样物质（EDLS）排泄进行了研究。在开始摄入1%氯化钠后，尿EDLS立即增加，然后在2周后恢复到基础水平。在开始摄入1%氯化钠后的2周内，3/6和4/6肾质量减少大鼠的尿钠排泄和尿EDLS均显著高于对照组。然而，两组之间的血压没有差异。EDLS的短暂增加可能在维持钠和水平衡方面起重要作用，但其短暂增加显然对血压升高没有影响。
