Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA.
J Int Neuropsychol Soc. 2012 Sep;18(5):787-98. doi: 10.1017/S135561771200046X. Epub 2012 May 24.
This study examined everyday action impairment in participants with Parkinson's disease dementia (PDD) by comparison with participants with Parkinson's disease-no dementia (PD) or Alzheimer's disease (AD) and in reference to a neuropsychological model. Participants with PDD (n = 20), PD (n = 20), or AD (n = 20) were administered performance-based measures of everyday functioning that allowed for the quantification of overall performance and error types. Also, caregiver ratings of functional independence were obtained. On performance-based tests, the PDD group exhibited greater functional impairment than the PD group but comparable overall impairment relative to the AD group. Error patterns did not differ between PDD and PD participants but the PDD group demonstrated a higher proportion of commission errors and lower proportion of omission errors relative to the AD group. Hierarchical regression analyses showed omission errors were significantly predicted by neuropsychological measures of episodic memory, whereas commission errors were predicted by both measures of general dementia severity (MMSE) and executive control. Everyday action impairment in PDD differs quantitatively from PD but qualitatively from AD and may be characterized by a relatively high proportion of commission errors-an error type associated with executive control deficits. (JINS, 2012, 18, 1-12).
本研究通过与帕金森病无痴呆（PD）或阿尔茨海默病（AD）患者比较，参照神经心理学模型，检查了帕金森病痴呆（PDD）患者的日常行为障碍。将 20 名 PDD 患者、20 名 PD 患者或 20 名 AD 患者进行了日常功能的基于表现的测量，这些测量允许量化整体表现和错误类型。此外，还获得了照顾者对功能独立性的评分。在基于表现的测试中，PDD 组表现出比 PD 组更大的功能障碍，但相对于 AD 组，整体障碍相当。PDD 和 PD 参与者的错误模式没有差异，但 PDD 组与 AD 组相比，表现出更高的冲动错误比例和更低的遗漏错误比例。层次回归分析表明，遗忘错误可以通过情景记忆的神经心理学测量显著预测，而冲动错误可以通过一般痴呆严重程度（MMSE）和执行控制的测量来预测。PDD 的日常行为障碍在数量上与 PD 不同，但在质量上与 AD 不同，其特点可能是冲动错误的比例相对较高，这是一种与执行控制缺陷相关的错误类型。（JINS，2012，18，1-12）。
