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鳞状细胞癌中热休克蛋白27和热休克蛋白70的表达：一项免疫组织化学研究。

HSP27 and HSP70 expression in squamous cell carcinoma: An immunohistochemical study.

作者信息

Deyhimi Parviz, Azmoudeh Faezeh

机构信息

Torabinejad Dental Research Center and Department of Oral and Maxillofacial Pathology, Isfahan University of Medical Sciences, Iran.

出版信息

Dent Res J (Isfahan). 2012 Mar;9(2):162-6. doi: 10.4103/1735-3327.95230.

DOI:10.4103/1735-3327.95230
PMID:22623932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3353692/
Abstract

BACKGROUND

Heat shock proteins (HSPs) are a family of proteins that are known to play a significant role in the repair of denatured proteins in the cell. It seems that cytoprotective properties of HSPs may help in malignant progression by facilitating tumor cell growth and survival. The purpose of this study is to evaluate HSP27 and HSP70 expression in various histopathological grades of squamous cell carcinoma (SCC).

MATERIALS AND METHODS

In this retrospective-analytical study, the sections of 51 formalin-fixed paraffin-embedded biopsy specimens of SCC from various sites of oral and paraoral regions and 10 normal oral mucosa were immunostained by Novolink Polymer technique to determine the expression of HSP27 and HSP70. Then the data were analyzed according to the Kruskal-Walis, Mann-Whitney and the Spearman correlation tests (P<0.05).

RESULTS

The expression of HSP27 in well-differentiated SCC was significantly higher than normal epithelium (P=0.007) and in moderately differentiated SCC higher than poorly-differentiated SCC (P=0.023). Inverse correlation was observed between HSP27 expression and SCC's histopathological grade (P=0.001, r=-0.448). There was no significant difference between HSP70 staining of specimens (P=0.38).

CONCLUSIONS

The present study revealed that the expression level of HSP27 was inversely related to histopathological grade of SCC and it may provide prognostic value for patients with SCC, but there was no significant relationship between the expression of HSP70 and histopathological grades of SCC.

摘要

背景

热休克蛋白（HSPs）是一类蛋白质，已知其在细胞内变性蛋白质的修复中发挥重要作用。HSPs的细胞保护特性似乎可能通过促进肿瘤细胞生长和存活而有助于恶性进展。本研究的目的是评估HSP27和HSP70在鳞状细胞癌（SCC）不同组织病理学分级中的表达。

材料与方法

在这项回顾性分析研究中，采用Novolink Polymer技术对51例来自口腔及口周不同部位的SCC福尔马林固定石蜡包埋活检标本切片和10例正常口腔黏膜进行免疫染色，以确定HSP27和HSP70的表达。然后根据Kruskal-Walis、Mann-Whitney和Spearman相关性检验分析数据（P<0.05）。

结果

HSP27在高分化SCC中的表达显著高于正常上皮（P=0.007），在中分化SCC中的表达高于低分化SCC（P=0.023）。观察到HSP27表达与SCC的组织病理学分级呈负相关（P=0.001，r=-0.448）。标本的HSP70染色之间无显著差异（P=0.38）。

结论

本研究表明，HSP27的表达水平与SCC的组织病理学分级呈负相关，它可能为SCC患者提供预后价值，但HSP70的表达与SCC的组织病理学分级之间无显著关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/dbb0cb746d18/DRJ-9-162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/a0a43d1ba2be/DRJ-9-162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/9c37c130f5b0/DRJ-9-162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/fe86682aeae9/DRJ-9-162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/dbb0cb746d18/DRJ-9-162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/a0a43d1ba2be/DRJ-9-162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/9c37c130f5b0/DRJ-9-162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/fe86682aeae9/DRJ-9-162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/034d/3353692/dbb0cb746d18/DRJ-9-162-g007.jpg

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2
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BMC Cancer. 2009 Jun 4;9:167. doi: 10.1186/1471-2407-9-167.
3
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Cancers (Basel). 2020 May 3;12(5):1151. doi: 10.3390/cancers12051151.
4
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Contemp Clin Dent. 2019 Apr-Jun;10(2):185-190. doi: 10.4103/ccd.ccd_101_18.
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Patholog Res Int. 2018 Apr 4;2018:4810751. doi: 10.1155/2018/4810751. eCollection 2018.
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