Landan G, Cohen G, Aharonowitz Y, Shuali Y, Graur D, Shiffman D
Interdisciplinary Program for Fostering Excellence, Tel Aviv University, Ramat Aviv, Israel.
Mol Biol Evol. 1990 Sep;7(5):399-406. doi: 10.1093/oxfordjournals.molbev.a040615.
The isopenicillin N synthase genes from three fungal species, three Gram-positive species, and one Gram-negative bacterial species share an unusually high sequence similarity. A phylogenetic analysis was carried out to determine which type of evolutionary scenario best accounts for this similarity. The most plausible scenario is one in which a horizontal gene-transfer event, from the prokaryotes to the eukaryotes, occurred at a time close to the divergence between the Gram-positive and the Gram-negative bacteria.
