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青蒿琥酯-咯萘啶治疗失败，尽管在从坦桑尼亚返回的旅行者的恶性疟原虫疟疾中，第 7 天的咯萘啶血药浓度足够。

Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.

机构信息

Infectious Diseases Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

出版信息

Malar J. 2012 May 25;11:176. doi: 10.1186/1475-2875-11-176.

DOI:10.1186/1475-2875-11-176
PMID:22632033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3416680/
Abstract

Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.

摘要

蒿甲醚-本芴醇目前是许多国家治疗恶性疟原虫疟疾的一线药物。本报告描述了一名从撒哈拉以南非洲返回的旅行者尽管药物浓度适宜但治疗仍失败的案例。基因分型证实了复发，并提示敏感性降低。蒿甲醚-本芴醇潜在的非最佳疗效突出表明需要在治疗后数周内对非免疫个体进行随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9cd/3416680/ac86dcf553d7/1475-2875-11-176-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9cd/3416680/ac86dcf553d7/1475-2875-11-176-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9cd/3416680/ac86dcf553d7/1475-2875-11-176-1.jpg

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