Department of Obstetrics and Gynecology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Prenat Diagn. 2012 Aug;32(8):797-802. doi: 10.1002/pd.3904. Epub 2012 May 27.
To test the fetal profile (FP) line, defined as the line that passes through the anterior border of the mandible and the nasion, as a reference line for forehead and mandible anomalies.
Volumes of 248 normal and 24 pathological fetuses (16-36 and 19-37 weeks' gestation, respectively) were analysed retrospectively. When the FP line passes anteriorly, across or posteriorly to the frontal bone, this was defined as 'negative', 'zero' or 'positive', respectively. When the FP line was positive the distance (F distance) between the FP line and the frontal bone was measured.
No cases with a negative FP line were found in the normal fetuses. Before 27 weeks' gestation the FP line was always 'zero' except in one case. After 27 weeks' gestation the FP line was 'positive' in up to 25% (F distance (mean, range): 2.8, 2.1-3.6 mm). The FP line correctly identified 13 cases with retrognathia, 5 cases with frontal bossing and 3 cases with a sloping forehead.
Although large prospective studies are needed, the FP line may be a useful tool to detect second trimester profile anomalies such as retrognathia, sloping forehead and frontal bossing with the possibility of quantifying the latter.
测试胎儿侧貌线（FP 线），即穿过下颌前缘和鼻根的线，作为额骨和下颌骨异常的参考线。
回顾性分析了 248 例正常胎儿和 24 例病理胎儿（分别为 16-36 周和 19-37 周妊娠）的体积。当 FP 线位于额骨前方、通过额骨或位于额骨后方时，分别定义为“负”、“零”或“正”。当 FP 线为正时，测量 FP 线与额骨之间的距离（F 距离）。
在正常胎儿中未发现 FP 线为负的病例。在 27 周妊娠前，FP 线始终为“零”，除了一例。在 27 周妊娠后，FP 线“正”的比例高达 25%（F 距离（均值，范围）：2.8、2.1-3.6mm）。FP 线正确识别了 13 例下颌后缩、5 例额骨前突和 3 例额骨倾斜的病例。
尽管需要进行大规模的前瞻性研究，但 FP 线可能是一种有用的工具，可以在中期妊娠中检测到侧貌异常，如下颌后缩、额骨前突和额骨倾斜，并有可能对后者进行定量分析。
