Verstegen J, Fargetton X, Donnay I, Ectors F
Small Animals Obstetric Clinic, Veterinary Faculty, University of Liège, Belgium.
Vet Rec. 1990 Oct 27;127(17):424-6.
A controlled trial was conducted to assess suitability of combinations of medetomidine and ketamine for the ovariectomy of cats, to investigate the possible side effects, and to compare medetomidine/ketamine with a combination of xylazine and ketamine. Three hundred and thirty-seven cats were submitted to surgery; 100 were anaesthetised with 80 micrograms/kg medetomidine and 5 mg/kg ketamine, 137 with 80 micrograms/kg medetomidine and 7.5 mg/kg ketamine, and 100 were anaesthetised with 1 mg/kg xylazine and 10 mg/kg ketamine. The combinations were injected intramuscularly in the same syringe. The anaesthesia provided by the medetomidine/ketamine combinations was characterised by good muscle relaxation, good analgesia and minimal side effects. The only difference between the two doses of ketamine was the length of the period of anaesthesia. The advantages of the medetomidine/ketamine combination in comparison with xylazine/ketamine were the need for a lower dose of ketamine, a longer duration of action and better analgesia. Similar side effects were observed with both medetomidine/ketamine and xylazine/ketamine combinations.
进行了一项对照试验，以评估美托咪定和氯胺酮联合用药对猫卵巢切除术的适用性，调查可能的副作用，并比较美托咪定/氯胺酮与赛拉嗪和氯胺酮联合用药的效果。337只猫接受了手术；100只猫用80微克/千克美托咪定和5毫克/千克氯胺酮麻醉，137只猫用80微克/千克美托咪定和7.5毫克/千克氯胺酮麻醉，100只猫用1毫克/千克赛拉嗪和10毫克/千克氯胺酮麻醉。这些联合用药通过同一注射器肌肉注射。美托咪定/氯胺酮联合用药提供的麻醉具有良好的肌肉松弛、良好的镇痛效果且副作用最小的特点。两种剂量氯胺酮之间的唯一区别在于麻醉持续时间。与赛拉嗪/氯胺酮相比，美托咪定/氯胺酮联合用药的优点是所需氯胺酮剂量较低、作用持续时间较长且镇痛效果更好。美托咪定/氯胺酮和赛拉嗪/氯胺酮联合用药观察到的副作用相似。
