Moens Y, Fargetton X
University of Ghent, Belgium.
Vet Rec. 1990 Dec 8;127(23):567-71.
The anaesthetic and physiological effects of a combination of 40 micrograms medetomidine with 2.5 ketamine, 5.0 or 7.5 mg/kg administered intramuscularly were compared with the effects of a combination of 1 mg/kg xylazine and 15 mg/kg ketamine. All the combinations rapidly induced an anaesthetic state that permitted endotracheal intubation, with the absence of the pedal reflex and with good muscle relaxation, and induced bradycardia that was less pronounced as the dose of ketamine was increased. All the combinations produced a decrease in respiratory rate. Increasing the dose of ketamine combined with medetomidine resulted in a very significant prolongation of the duration of anaesthesia, the duration of muscle relaxation and the arousal time. The duration of the anaesthetic effects of 40 micrograms/kg medetomidine with 5 mg/kg ketamine was comparable to that provided by the recommended xylazine/ketamine combination but the period of muscle relaxation was significantly longer. The recovery from medetomidine/ketamine took longer than recovery from xylazine/ketamine but there were fewer side effects.
将40微克美托咪定与2.5、5.0或7.5毫克/千克氯胺酮联合肌肉注射的麻醉和生理效应，与1毫克/千克赛拉嗪和15毫克/千克氯胺酮联合使用的效应进行了比较。所有联合用药均能迅速诱导出允许进行气管插管的麻醉状态，无足趾反射且肌肉松弛良好，并引起心动过缓，随着氯胺酮剂量的增加，心动过缓症状减轻。所有联合用药均导致呼吸频率降低。增加与美托咪定联合使用的氯胺酮剂量会导致麻醉持续时间、肌肉松弛持续时间和苏醒时间显著延长。40微克/千克美托咪定与5毫克/千克氯胺酮的麻醉效果持续时间与推荐的赛拉嗪/氯胺酮联合用药相当，但肌肉松弛时间明显更长。美托咪定/氯胺酮的苏醒时间比赛拉嗪/氯胺酮长，但副作用较少。
