Life Science R&D Center, Sinil Pharmaceutical Co., Ltd., Chungju, Korea.
Arch Pharm Res. 2012 May;35(5):801-5. doi: 10.1007/s12272-012-0506-z. Epub 2012 May 29.
The inhibition of Interleukin-1beta (IL-1β) is of substantial interest for the treatment of rheumatoid arthritis. Using an in vitro assay with RAW 264.7 cells, oxo-acetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester (1) was isolated from the roots of Paeonia suffruticosa Andrews as an inhibitor of IL-1β with an IC(50) value of 56 μM. Compound 1 is a novel phenylesteric compound from P. suffruticosa Andrews. Compound 1 was shown to inhibit the production of pro-inflammatory cytokines in RAW 264.7 cells. Thus, a possible new action of novel compound is provided explaining the anti-rheumatoid arthritic properties of P. suffruticosa Andrews.
白芍药根中的一种新苯酯类化合物 1 对白细胞介素-1β（IL-1β）有抑制作用，可用于治疗类风湿关节炎。采用 RAW 264.7 细胞体外试验，从白芍 Paeonia suffruticosa Andrews 根中分离得到化合物 1，对白细胞介素-1β的半数抑制浓度（IC50）为 56 μM。1 是一种新型苯酯类化合物。化合物 1 可抑制 RAW 264.7 细胞促炎细胞因子的产生。因此，为解释白芍的抗类风湿关节炎特性，提供了一种新型化合物的可能新作用。
