Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
ACS Nano. 2012 Jun 26;6(6):4947-54. doi: 10.1021/nn300456z. Epub 2012 Jun 5.
Thermal decomposition of organometallic precursors has been found to generate highly crystalline iron oxide (IO) nanocrystals that display superior MR contrast and lower polydispersity than IO nanocrystals synthesized by aqueous precipitation. In the present study, the in vivo characteristics of IO nanocrystals prepared by the thermal decomposition route and then coated with a phospholipid containing a pendant poly(ethylene glycol) chain are examined. The size and surface chemistry of the IO nanocrystal influence the biodistibution, the rate of biodegradation and bioclearance, and the biodegradation products. We conclude that the in vivo fate of PEGylated monodisperse IO nanocrystals and the iron, phospholipid, and oleic acid biodegradation products may influence the cellular environments in the organs and blood that can determine their safety in the body.
有机金属前体的热分解已被发现能生成高结晶度的氧化铁 (IO) 纳米晶体，与通过水相沉淀法合成的 IO 纳米晶体相比，这些纳米晶体具有更高的磁共振对比和更低的多分散性。在本研究中，我们研究了通过热分解途径制备的 IO 纳米晶体，然后用含有侧挂聚乙二醇 (PEG) 链的磷脂进行包覆的 IO 纳米晶体的体内特性。IO 纳米晶体的尺寸和表面化学性质影响其生物分布、生物降解和生物清除速率，以及生物降解产物。我们得出结论，PEG 化单分散 IO 纳米晶体和铁、磷脂和油酸的生物降解产物的体内命运可能会影响器官和血液中的细胞环境，从而决定它们在体内的安全性。
