近红外光响应的细胞内药物和 siRNA 释放使用具有寡核苷酸封端的硅壳的金纳米组装体。
Near-infrared light-responsive intracellular drug and siRNA release using au nanoensembles with oligonucleotide-capped silica shell.
机构信息
Department of Chemistry and Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan, 701 Taiwan.
出版信息
Adv Mater. 2012 Jul 3;24(25):3309-14. doi: 10.1002/adma.201200785. Epub 2012 May 31.
PMID:22648937
Abstract
Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery.
摘要
利用金纳米棒（Au NRs）吸收近红外光的特性，开发了一种近红外响应的寡核苷酸门控聚集体，用于进行细胞内药物输送。使用寡核苷酸生物门控可以将 siRNA 释放到细胞中，用于翻译调控以及用于抗癌药物输送的细胞毒性。
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