通过 microRNAs 进行诱饵活性：治疗意义。
Decoy activity through microRNAs: the therapeutic implications.
机构信息
The University of Texas MD Anderson Cancer Center, Department of Experimental Therapeutics, Houston, TX 77030, USA.
出版信息
Expert Opin Biol Ther. 2012 Sep;12(9):1153-9. doi: 10.1517/14712598.2012.693470. Epub 2012 Jun 1.
INTRODUCTION
microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a posttranscriptional level by binding to 5'UTR, coding regions or 3'UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs.
AREAS COVERED
Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA-RNA language that involves cross-talk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs.
EXPERT OPINION
The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design.
简介
微小 RNA（miRNAs）是一类小型非编码 RNA，在包括癌症在内的多种疾病中失调。miRNAs 通过与信使 RNA（mRNA）的 5'UTR、编码区或 3'UTR 结合，在转录后水平上调节基因表达，抑制 mRNA 翻译或导致 mRNA 降解。同一种 miRNA 可以有多个 mRNA 靶标，同一种 mRNA 也可以被多种 miRNA 调控。
涵盖领域
最近，几个研究小组的开创性贡献表明，miRNAs 是一种 RNA-RNA 语言的组成部分，该语言通过诱饵机制涉及竞争内源性 RNA 之间的串扰。我们回顾了描述 miRNAs 作为生物诱饵活性的参与者的研究。miRNAs 可以被竞争内源性 RNA 捕获，或者与具有结合 mRNA 结合位点的蛋白质相互作用。
专家意见
miRNA 诱饵功能对人类疾病治疗方法的设计具有重要意义，包括克服药物治疗耐药性的特定方法和未来基于 miRNA 的临床试验设计。
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