Department of Diagnostic Radiology, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Eur J Radiol. 2012 Nov;81(11):3061-6. doi: 10.1016/j.ejrad.2012.04.028. Epub 2012 May 29.
To test the feasibility of apparent diffusion coefficient (ADC) value obtained with 3.0 T diffusion-weighted imaging (DWI) in the characterization of renal cell carcinomas (RCC) with different pathological subtypes and grades.
A total of 137 patients who were diagnosed with RCC and underwent DWI were included in this study. The diagnosis was confirmed by pathological examination of surgical specimens. Images of DWI were obtained with b values of 0 and 800 s/mm2. The ADC values in the solid area of tumors and in the corresponding regions of contralateral normal renal parenchyma were measured and analyzed statistically.
The mean ADC value was significantly lower in RCC (1.381±0.444×10(-3) mm2/s) than in normal renal parenchyma (2.232±0.221×10(-3) mm2/s) (P<0.001). The ADC value was also statistically different between clear cell RCC (CCRCC) and non-CCRCC, and between different grades of CCRCC except grade I vs II and grade III vs IV.
ADC measurement on 3.0 T DWI provides useful information in diagnostic work-up of RCC in terms of differentiation of RCC and normal renal parenchyma, and characterization of RCC with different pathological subtypes and grades.
测试 3.0T 扩散加权成像（DWI）获得的表观扩散系数（ADC）值在不同病理亚型和分级的肾细胞癌（RCC）中的特征性表现的可行性。
本研究共纳入 137 例经病理检查证实为 RCC 并接受 DWI 检查的患者。DWI 图像的 b 值分别为 0 和 800 s/mm2。测量并统计分析肿瘤实性区域及对侧正常肾实质相应区域的 ADC 值。
RCC 的平均 ADC 值（1.381±0.444×10(-3)mm2/s）显著低于正常肾实质（2.232±0.221×10(-3)mm2/s）（P<0.001）。在透明细胞 RCC（CCRCC）和非 CCRCC 之间，以及 CCRCC 的不同分级之间（除 I 级与 II 级和 III 级与 IV 级外），ADC 值也存在统计学差异。
3.0T DWI 的 ADC 值测量在 RCC 的诊断工作中提供了有用的信息，可用于区分 RCC 和正常肾实质，以及不同病理亚型和分级的 RCC 的特征性表现。
