Department of Obstetrics and Gynecology, Acibadem University School of Medicine, Istanbul, Turkey.
Placenta. 2012 Aug;33(8):591-8. doi: 10.1016/j.placenta.2012.04.011. Epub 2012 May 30.
Autophagy is a burgeoning area of research from yeast to humans. Although previously described as a death pathway, autophagy is now considered an important survival phenomenon in response to environmental stressors to which most organs are exposed. Despite an ever expanding literature in non-placental cells, studies of autophagy in the placenta are lagging. We review the regulation of autophagy, summarize available placental studies of autophagy, and highlight potential areas for future research. We believe that such studies will yield novel insights into how placentas protect the survival of the species by "self-eating".
自噬是一个从酵母到人都在深入研究的领域。虽然以前被描述为一种死亡途径，但自噬现在被认为是一种重要的生存现象，它可以响应大多数器官都面临的环境胁迫。尽管非胎盘细胞的相关文献不断增加，但胎盘自噬的研究却滞后不前。我们综述了自噬的调控，总结了现有的胎盘自噬研究，并强调了未来研究的潜在领域。我们相信，这些研究将为胎盘如何通过“自噬”来保护物种的生存提供新的见解。
