Sroga Julie M, Ma Xinghong, Das Sanjoy K
Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Front Biosci (Schol Ed). 2012 Jun 1;4(4):1475-86. doi: 10.2741/s347.
Polyploidy has been reported in several animal cells, as well as within humans; however the mechanism of developmental regulation of this process remains poorly understood. Polyploidy occurs in normal biologic processes as well as in pathologic states. Decidual polyploid cells are terminally differentiated cells with a critical role in continued uterine development during embryo implantation and growth. Here we review the mechanisms involved in polyploidy cell formation in normal developmental processes, with focus on known regulatory aspects in decidual cells.
多倍体现象已在多种动物细胞以及人类细胞中被报道；然而，这一过程的发育调控机制仍知之甚少。多倍体现象既出现在正常生物学过程中，也出现在病理状态下。蜕膜多倍体细胞是终末分化细胞，在胚胎着床和生长期间子宫的持续发育中起关键作用。在此，我们综述正常发育过程中多倍体细胞形成所涉及的机制，重点关注蜕膜细胞中已知的调控方面。
