Lövgren K, Kåberg H, Morein B
National Veterinary Institute, Department of Virology, Uppsala, Sweden.
Clin Exp Immunol. 1990 Dec;82(3):435-9. doi: 10.1111/j.1365-2249.1990.tb05467.x.
An experimental influenza virus (A/PR/8/34(H1N1] vaccine was tested and evaluated in mice. The mice were inoculated once or twice intranasally or subcutaneously with 1 or 10 micrograms of iscoms prior to challenge with high dose of live virus. It was demonstrated that two intranasal administrations were as efficient as two s.c. administrations, both routes inducing high levels of antibody and protection against challenge infection. With a one-dose regimen, the s.c. route induced a somewhat higher antibody response than the intranasal route; this might be explained by technical difficulties connected with an intranasal administration.
一种实验性流感病毒（A/PR/8/34[H1N1]）疫苗在小鼠身上进行了测试和评估。在以高剂量活病毒进行攻击之前，给小鼠经鼻内或皮下接种1或10微克免疫刺激复合物，接种一次或两次。结果表明，两次鼻内给药与两次皮下给药效果相同，两种途径均能诱导高水平抗体并提供针对攻击感染的保护。采用单剂量方案时，皮下途径诱导的抗体反应略高于鼻内途径；这可能是由于鼻内给药存在技术困难所致。
