Cohen I, Tenenbaum E, Fejgin M, Michaeli G, Beyth Y, Sarov I
Department of Obstetrics and Gynecology A, Meir General Hospital, Kfar Saba, Israel.
Gynecol Obstet Invest. 1990;30(3):155-8. doi: 10.1159/000293249.
A case control study was performed to examine possible morbidity associated with Chlamydia trachomatis in 15 pregnant women with idiopathic preterm premature rupture of the membranes (PROM; group A), and in two control groups, 35 healthy preterm pregnant women (group B), and 43 healthy pregnant women at term (group C). Serum C. trachomatis IgG and IgA specific antibodies were determined using the single serovar (L2) inclusion immunoperoxidase assay. There were no significant differences in the prevalence rate of elevated levels of chlamydia IgG specific antibodies (titer greater than or equal to 1:128) between pregnant women suffering from idiopathic preterm PROM, as compared to healthy preterm and term pregnant women (20, 28 and 26%, respectively). Nor were there any significant differences in the prevalence rate of elevated levels of chlamydia IgA specific antibodies (titer greater than or equal to 1:16) between pregnant women with idiopathic preterm PROM, as compared to healthy preterm and term pregnant women (20, 20 and 17%, respectively). These findings do not support the assumption that C. trachomatis may play role in preterm PROM.
开展了一项病例对照研究，以调查15例特发性胎膜早破的孕妇（A组）、两个对照组（35例健康的早产孕妇（B组）和43例足月健康孕妇（C组））中与沙眼衣原体相关的可能发病率。使用单血清型（L2）包涵体免疫过氧化物酶测定法测定血清沙眼衣原体IgG和IgA特异性抗体。与健康的早产和足月孕妇相比，特发性早产胎膜早破的孕妇中沙眼衣原体IgG特异性抗体水平升高（滴度大于或等于1:128）的患病率无显著差异（分别为20%、28%和26%）。与健康的早产和足月孕妇相比，特发性早产胎膜早破的孕妇中沙眼衣原体IgA特异性抗体水平升高（滴度大于或等于1:16）的患病率也无显著差异（分别为20%、20%和17%）。这些发现不支持沙眼衣原体可能在早产胎膜早破中起作用的假设。
