Cohen I, Tenenbaum E, Fejgin M, Altaras M, Ben-Aderet N, Sarov I
Department of Obstetrics and Gynecology A, Meir General Hospital, Kfar Saba Israel.
Am J Obstet Gynecol. 1988 Mar;158(3 Pt 1):579-82. doi: 10.1016/0002-9378(88)90031-2.
A case-control study was undertaken to examine the possible morbidity associated with Chlamydia trachomatis in 28 pregnant women having idiopathic premature contractions, in 35 healthy preterm pregnant women, and in 43 healthy pregnant women at term. Serum C. trachomatis IgG- and IgA-specific antibodies were determined by the single serovar inclusion immunoperoxidase assay. There were no significant differences in the prevalence rate of elevated C. trachomatis IgG-specific antibodies (titer greater than or equal to 1:128) between pregnant women suffering from idiopathic premature contractions as compared with healthy preterm and term pregnant women (11%, 28%, and 26%, respectively). The known prevalence rate in a normal healthy population is 23%. The prevalence rate of elevated C. trachomatis IgA-specific antibodies (titer greater than or equal to 1:16) was significantly lower in the pregnant women with idiopathic premature contractions as compared with the healthy preterm and term pregnant women (0%, 20%, and 17%, respectively; p less than 0.002 and p less than 0.012). These findings do not support the assumption that C. trachomatis has a role in premature contractions.
开展了一项病例对照研究，以检查28例有特发性早产宫缩的孕妇、35例健康的早产孕妇和43例足月健康孕妇中与沙眼衣原体相关的可能发病率。通过单血清型包涵体免疫过氧化物酶测定法测定血清沙眼衣原体IgG和IgA特异性抗体。患有特发性早产宫缩的孕妇与健康的早产和足月孕妇相比，沙眼衣原体IgG特异性抗体升高（滴度大于或等于1:128）的患病率无显著差异（分别为11%、28%和26%）。正常健康人群中的已知患病率为23%。与健康的早产和足月孕妇相比，患有特发性早产宫缩的孕妇中沙眼衣原体IgA特异性抗体升高（滴度大于或等于1:16）的患病率显著较低（分别为0%、20%和17%；p<0.002和p<0.012）。这些发现不支持沙眼衣原体在早产宫缩中起作用的假设。
