Hu Shuai, Wang Fang-Zhan, Liu Zhen-Ning, Liu Ya-Pei, Yu Xiao-Lin
Institute of Vegetable Sciences, Zhejiang University, Hangzhou 310058, China.
Yi Chuan. 2012 May;34(5):560-72. doi: 10.3724/sp.j.1005.2012.00560.
Abscisic acid (ABA) is a phytohormone that plays critical roles in numerous developmental stages as well as in adaptive responses to biotic and abiotic stresses. Recent breakthroughs in the field of ABA signaling have indicated that there are three major components, PYR/PYL/RCAR (an ABA receptor), type 2C protein phosphates (PP2C, a negative regulator), and SNF1-related protein kinase 2 (SnRK2, a positive regulator). Further results show that these three proteins construct a double negative regulatory system, PYR/PYL/RCAR-| PP2C-| SnRK2, to regulate ABA signal responses in plant cells. Moreover, the combination patterns of these components in vivo are restricted by spatio-temporal and biochemical determinants and the combinational variation in the ABA signalosome is specific to different ABA signal responses. This review summarizes recent advances of study on the molecular basis and regulatory mechanism of PYR/PYL/RCAR-mediated ABA signaling pathway and PYR/PYL/RCAR-PP2C-SnRK2 complex-mediated ABA signal regulation network in plants. The perspectives related to this study are proposed.
脱落酸（ABA）是一种植物激素，在植物多个发育阶段以及对生物和非生物胁迫的适应性反应中发挥关键作用。ABA信号领域的最新突破表明，存在三个主要成分，即PYR/PYL/RCAR（一种ABA受体）、2C型蛋白磷酸酶（PP2C，一种负调控因子）和SNF1相关蛋白激酶2（SnRK2，一种正调控因子）。进一步的研究结果表明，这三种蛋白质构建了一个双负调控系统，即PYR/PYL/RCAR-|PP2C-|SnRK2，以调节植物细胞中的ABA信号反应。此外，这些成分在体内的组合模式受到时空和生化决定因素的限制，并且ABA信号体中的组合变化对于不同的ABA信号反应具有特异性。本文综述了PYR/PYL/RCAR介导的ABA信号通路的分子基础和调控机制以及PYR/PYL/RCAR-PP2C-SnRK2复合物介导的植物ABA信号调控网络的研究进展，并提出了与该研究相关的展望。
