The First Affiliated Hospital, Xiamen University Medical School, Xiamen, China.
CNS Neurosci Ther. 2012 Jun;18(6):457-60. doi: 10.1111/j.1755-5949.2012.00326.x.
Human cytomegalovirus (HCMV) is implicated in several cardiovascular disorders, including atherosclerosis, coronary heart disease, and cardiac transplant arteriopathy. We aimed to evaluate the relationship between HCMV and stroke.
Real-time polymerase chain reaction (PCR) and ELISA were performed on plasma samples isolated from 200 patients diagnosed with stroke and 200 controls. All participants belonged to the Stroke Hypertension Investigation in Genetics (SHINING) study.
HCMV seropositivity was higher in the stroke group than in controls (55.0% vs. 23.5%; P < 0.0001). The presence of HCMV DNA increased the risk of stroke (unadjusted odds ratio [OR], 3.98; 95% confidence interval [CI], 2.59 to 6.11; P < 0.0001). Risks were also increased for the subtypes ischemic stroke (unadjusted OR, 4.01; 95% CI, 2.57-6.24; P < 0.0001) and hemorrhagic stroke (unadjusted OR, 3.80; 95% CI, 1.64-8.78; P= 0.0018). Increased risk with HCMV remained significant after adjustment for age, sex, body mass index, hypertension, and smoking (ischemic stroke: adjusted OR, 4.07; 95% CI, 2.52-6.32; P < 0.0001; hemorrhagic stroke: adjusted OR, 3.88; 95% CI, 1.61-9.36; P= 0.0026).
We demonstrate a novel link between HCMV infection and stroke. These findings may provide important insights into the pathogenesis of stroke.
人巨细胞病毒（HCMV）与多种心血管疾病有关，包括动脉粥样硬化、冠心病和心脏移植后动脉病。我们旨在评估 HCMV 与中风之间的关系。
对 200 名确诊为中风的患者和 200 名对照者的血浆样本进行实时聚合酶链反应（PCR）和酶联免疫吸附试验（ELISA）。所有参与者均属于中风高血压遗传学研究（SHINING）。
中风组 HCMV 血清阳性率高于对照组（55.0%比 23.5%；P<0.0001）。HCMV DNA 的存在增加了中风的风险（未经调整的优势比[OR]，3.98；95%置信区间[CI]，2.59 至 6.11；P<0.0001）。缺血性中风（未经调整的 OR，4.01；95%CI，2.57 至 6.24；P<0.0001）和出血性中风（未经调整的 OR，3.80；95%CI，1.64 至 8.78；P=0.0018）的亚型风险也增加。在校正年龄、性别、体重指数、高血压和吸烟后，HCMV 与风险增加仍然显著（缺血性中风：调整后的 OR，4.07；95%CI，2.52 至 6.32；P<0.0001；出血性中风：调整后的 OR，3.88；95%CI，1.61 至 9.36；P=0.0026）。
我们证明了 HCMV 感染与中风之间存在新的联系。这些发现可能为中风的发病机制提供重要的见解。
