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乳制品摄入与澳大利亚糖尿病发病风险的关系:澳大利亚糖尿病、肥胖和生活方式研究(AusDiab)。

The association between dairy food intake and the incidence of diabetes in Australia: the Australian Diabetes Obesity and Lifestyle Study (AusDiab).

机构信息

Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.

出版信息

Public Health Nutr. 2013 Feb;16(2):339-45. doi: 10.1017/S1368980012001310. Epub 2012 Jun 7.

DOI:10.1017/S1368980012001310
PMID:22672923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10271426/
Abstract

OBJECTIVE

Several studies have suggested that dairy food may reduce the risk of obesity and metabolic abnormalities but few have been able to conclusively demonstrate that it reduces the risk of diabetes. The aim of the present analysis was to investigate if dairy food intake independently reduces the risk of diabetes.

DESIGN

The Australian Diabetes Obesity and Lifestyle Study (AusDiab) is a national, population-based, prospective survey conducted over 5 years. Baseline measurements included a 121-item FFQ, anthropometrics and an oral glucose tolerance test.

SETTING

Forty-two randomly selected clusters across Australia.

SUBJECTS

Adults aged ≥25 years who participated in the baseline survey and returned to follow-up 5 years later.

RESULTS

A total of 5582 participants with complete data were eligible for analysis, 209 of whom had incident diabetes. Compared with men in the first tertile of dairy food intake, men in the third tertile had a significantly reduced risk of developing diabetes after adjustment for age, sex, total energy intake, family history of diabetes, education, physical activity, smoking status, fasting serum TAG and HDL cholesterol, systolic blood pressure, waist circumference and hip circumference (OR = 0·53, 95 % CI 0·29, 0·96; P = 0·033). A similar non-significant association was observed in women.

CONCLUSIONS

Dietary patterns that incorporate high intakes of dairy food may reduce the risk of diabetes among men. Further investigation into the relationship between dairy food intake and diabetes needs to be undertaken to fully understand the potential mechanism of this observation.

摘要

目的

多项研究表明,乳制品可能降低肥胖和代谢异常的风险,但很少有研究能够明确证明其可降低糖尿病风险。本分析旨在研究乳制品的摄入是否可独立降低糖尿病风险。

设计

澳大利亚糖尿病、肥胖与生活方式研究(AusDiab)是一项全国性、基于人群、前瞻性研究,历时 5 年。基线测量包括 121 项食物频数问卷、人体测量学和口服葡萄糖耐量试验。

地点

澳大利亚 42 个随机选择的集群。

受试者

≥25 岁、参加基线调查并在 5 年后返回随访的成年人。

结果

共有 5582 名数据完整的参与者符合分析条件,其中 209 名发生了糖尿病。在校正年龄、性别、总能量摄入、糖尿病家族史、教育、身体活动、吸烟状况、空腹血清 TAG 和高密度脂蛋白胆固醇、收缩压、腰围和臀围后,与乳制品摄入量处于第一 tertile 的男性相比,摄入量处于第三 tertile 的男性发生糖尿病的风险显著降低(OR = 0·53,95 % CI 0·29, 0·96;P = 0·033)。女性也观察到类似的非显著相关性。

结论

富含乳制品的饮食模式可能降低男性的糖尿病风险。需要进一步研究乳制品摄入与糖尿病之间的关系,以充分了解这一观察结果的潜在机制。

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