Department Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
Planta Med. 2012 Jun;78(10):1024-6. doi: 10.1055/s-0032-1314949. Epub 2012 Jun 6.
A number of flavonoids including casticin and artemetin from Artemisia annua have shown synergism with artemisinin against Plasmodium falciparum, but it is unclear if the flavonoids are also extracted into a tea infusion of the plant. Using a tea infusion preparation protocol that was reported to be highly effective for artemisinin extraction, we measured casticin and artemetin extraction. There was only a 1.8 % recovery of casticin in the infusion while artemetin was undetectable. After 24 hr storage at room temperature, casticin yield declined by 40 %. These results show that although a tea infusion of the plant may extract artemisinin, the polymethoxylated flavonoids casticin and artemetin are poorly extracted and lost with storage at room temperature and thus, the tea infusion appears to lose synergistic value.
一些黄酮类化合物，包括来自青蒿的紫铆素和青蒿素，已显示出与青蒿素对疟原虫的协同作用，但尚不清楚这些黄酮类化合物是否也被提取到植物的茶浸液中。我们使用了一种被报道对青蒿素提取非常有效的茶浸液制备方案来测量紫铆素和青蒿素的提取情况。在浸液中，紫铆素的回收率只有 1.8%，而青蒿素则无法检测到。在室温下储存 24 小时后，紫铆素的产量下降了 40%。这些结果表明，尽管植物的茶浸液可能提取青蒿素，但多甲氧基黄酮类化合物紫铆素和青蒿素的提取效果很差，并且在室温下储存时会丢失，因此，茶浸液似乎失去了协同作用的价值。
