Elford B C, Roberts M F, Phillipson J D, Wilson R J
Clinical Research Centre, Harrow, Middlesex, UK.
Trans R Soc Trop Med Hyg. 1987;81(3):434-6. doi: 10.1016/0035-9203(87)90161-1.
Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.
使用基于[3H]次黄嘌呤掺入恶性疟原虫克隆系同步培养物的体外生长测定法，研究了黄酮类化合物紫花牡荆素和青蒿亭与氯喹和青蒿素（QHS）抗疟活性之间的相互作用。紫花牡荆素，以及程度稍轻的青蒿亭，选择性地增强了QHS对生长的抑制作用，但对氯喹的活性影响很小。这些发现表明，从其中分离出QHS的青蒿中所含的黄酮类化合物，可能会显著改变这种新型抗疟药物在治疗耐氯喹疟疾方面的临床潜力。
