Laboratoire des Procédés Biologiques, Génie Enzymatique et Microbien-ProBioGEM, UPRES-EA 1026, Polytech'Lille/IUT A, Université Lille Nord de France-Sciences et Technologies, USTL, 59655 Villeneuve d'Ascq Cedex, France.
Appl Microbiol Biotechnol. 2012 Aug;95(3):593-600. doi: 10.1007/s00253-012-4181-2. Epub 2012 Jun 9.
A new family of lipopeptides produced by Bacillus thuringiensis, the kurstakins, was discovered in 2000 and considered as a biomarker of this species. Kurstakins are lipoheptapeptides displaying antifungal activities against Stachybotrys charatum. Recently, the biosynthesis mechanism, the regulation of this biosynthesis and the potential new properties of kurstakins were described in the literature. In addition, kurstakins were also detected in other species belonging to Bacillus genus such as Bacillus cereus. This mini-review gathers all the information about these promising bioactive molecules.
2000 年，人们发现了苏云金芽孢杆菌产生的一类新型脂肽——库斯塔克菌素，它被认为是该菌种的生物标志物。库斯塔克菌素是一种具有抗真菌活性的七肽脂肽，可抑制串珠镰刀菌生长。最近，人们对库斯塔克菌素的生物合成机制、生物合成调控以及潜在的新特性进行了研究。此外，在芽孢杆菌属的其他一些物种中，如蜡状芽孢杆菌，也检测到了库斯塔克菌素的存在。本文对这些具有广阔应用前景的生物活性分子进行了综述。
