Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55101, Mainz, Germany.
Eur J Epidemiol. 2012 Jun;27(6):419-29. doi: 10.1007/s10654-012-9698-2. Epub 2012 Jun 8.
Commercial airline pilots are exposed to cosmic radiation and other specific occupational factors, potentially leading to increased cancer mortality. This was analysed in a cohort of 6,000 German cockpit crew members. A mortality follow-up for the years 1960-2004 was performed and occupational and dosimetry data were collected for this period. 405 deaths, including 127 cancer deaths, occurred in the cohort. The mortality from all causes and all cancers was significantly lower than in the German population. Total mortality decreased with increasing radiation doses (rate ratio (RR) per 10 mSv: 0.85, 95 % CI: 0.79, 0.93), contrasting with a non-significant increase of cancer mortality (RR per 10 mSv: 1.05, 95 % CI: 0.91, 1.20), which was restricted to the group of cancers not categorized as radiogenic in categorical analyses. While the total and cancer mortality of cockpit crew is low, a positive trend of all cancer with radiation dose is observed. Incomplete adjustment for age, other exposures correlated with duration of employment and a healthy worker survivor effect may contribute to this finding. More information is expected from a pooled analysis of updated international aircrew studies.
商业航空公司飞行员暴露于宇宙辐射和其他特定职业因素下，可能会导致癌症死亡率增加。这在一组 6000 名德国驾驶舱机组人员中进行了分析。对 1960 年至 2004 年期间的死亡率进行了随访，并在此期间收集了职业和剂量学数据。该队列中发生了 405 例死亡，包括 127 例癌症死亡。所有原因和所有癌症的死亡率明显低于德国人群。总死亡率随辐射剂量的增加而降低（每 10mSv 的比率比 (RR)：0.85，95%置信区间：0.79，0.93），与癌症死亡率的非显著增加形成对比（每 10mSv 的 RR：1.05，95%置信区间：0.91，1.20），后者仅局限于分类分析中未归类为放射性的癌症组。虽然驾驶舱机组人员的总死亡率和癌症死亡率较低，但观察到所有癌症与辐射剂量呈正相关趋势。对于年龄、与就业时间相关的其他暴露因素的不完全调整以及健康工人幸存者效应可能促成了这一发现。预计从更新的国际机组人员研究的汇总分析中可以获得更多信息。
