Institute of Biomedicine, Biochemistry and Developmental Biology, University of Helsinki, Finland.
Cell Mol Life Sci. 2012 Aug;69(15):2465-8. doi: 10.1007/s00018-012-1043-0. Epub 2012 Jun 9.
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis?
过氧化物酶体增殖物激活受体-γ 共激活因子-1α（PGC-1α）是一种转录共激活因子，它对线粒体功能有积极影响。越来越多的数据支持这一概念，包括对 PGC-1α 基因缺失小鼠的研究，这表明 PGC-1α 是一种能够促进细胞代谢和促进细胞存活的拯救因子。然而，最近的一项研究表明，腺相关病毒介导的 PGC-1α 过表达导致多巴胺能神经元明显的细胞退化，这对这一观点提出了质疑。如何理解这一点，这些看似矛盾的发现能告诉我们一些关于 PGC-1α 在细胞应激和神经元动态平衡控制中的作用吗？
