Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad, Maharashtra, India.
Drug Dev Ind Pharm. 2013 Sep;39(9):1263-72. doi: 10.3109/03639045.2012.694610. Epub 2012 Jun 11.
In recent years, nanosponges (NS) have gained tremendous impetus in drug delivery through nanotechnology. Nanosponges are capable of providing solutions for several formulation related problems. Through this review, scientists working in the field of nanotechnology can have an insight into the techniques of preparation, characterization and applications of NS. Owing to their small size and porous nature they can bind poorly-soluble drugs within their matrix and improve their bioavailability. They can be crafted for targeting drugs to specific sites, prevent drug and protein degradation and prolong drug release in a controlled manner. This review attempts to elaborate different schemes of synthesis of NS and their characterization. Factors affecting drug loading and release have been enumerated. Due to their advantages, NS have not only been explored for their pharmaceutical applications but also have large popularity in allied sciences, especially in water purification.
近年来，纳米海绵（NS）在通过纳米技术进行药物输送方面取得了巨大的动力。纳米海绵能够为解决几种制剂相关问题提供解决方案。通过本次综述，纳米技术领域的科学家可以深入了解 NS 的制备技术、特性和应用。由于其体积小且多孔，它们可以将疏水性药物结合在其基质中，提高生物利用度。它们可以被设计成靶向特定部位的药物，防止药物和蛋白质的降解，并以可控的方式延长药物释放。本综述试图详细阐述 NS 的不同合成方案及其特性。列举了影响药物负载和释放的因素。由于其优势，NS 不仅在药物应用方面得到了探索，而且在相关科学领域，特别是在水净化方面也得到了广泛的应用。
