Beijing Institute of Transfusion Medicine, Beijing 100850, PR China.
Mol Med Rep. 2012 Sep;6(3):581-4. doi: 10.3892/mmr.2012.934. Epub 2012 Jun 6.
Atrial fibrillation (AF) may occur and persist due to atrial remodeling exacerbated by inflammation. However, whether inflammatory cytokines, such as serum amyloid protein A (SAA), are elevated in patients with atrial arrhythmias remains unclear. In a case-control study design, serum levels of inflammatory cytokines SAA, IL-1, IL-6, TNF-α and high-sensitivity C-reactive protein (hsCRP) were compared between 122 patients with AF and 63 non-AF controls. Of 122 AF patients, 48 had lone AF and 74 organic AF; 65 had paroxysmal AF, 36 persistent AF and 21 permanent AF. In unadjusted analyses, the levels of SAA, hsCRP, TNF-αP, IL-1 and IL-6 were significantly higher in AF patients compared to control patients (P<0.01). Patients with permanent and persistent AF had higher serum levels of inflammatory cytokines than those with paroxysmal AF; all AF patients had higher serum levels than controls (P<0.05). Using a multivariate logistic regression analysis, we found that SAA (OR 3.11; 95% CI, 1.12-6.05), hsCRP (OR 2.53; 95% CI, 1.17-4.38), TNF-α (OR 1.80; 95% CI, 1.03-3.20) and IL-6 (OR 1.21; 95% CI, 0.68-2.87) were correlated with AF (P<0.05). SAA and related inflammatory cytokines are elevated in AF patients. This study is the first to document elevated SAA in AF patients. Although the cause of elevated SAA levels in AF patients remains unknown, elevated SAA may reflect an inflammatory state that promotes the occurrence and persistence of AF.
心房颤动（AF）可能由于炎症加重的心房重构而发生并持续存在。然而，患有心房性心律失常的患者中是否存在升高的炎症细胞因子，如血清淀粉样蛋白 A（SAA），尚不清楚。在病例对照研究设计中，比较了 122 例 AF 患者和 63 例非-AF 对照组之间炎症细胞因子 SAA、IL-1、IL-6、TNF-α和高敏 C 反应蛋白（hsCRP）的血清水平。在 122 例 AF 患者中，48 例为孤立性 AF，74 例为器质性 AF；65 例为阵发性 AF，36 例持续性 AF，21 例永久性 AF。在未调整的分析中，与对照组相比，AF 患者的 SAA、hsCRP、TNF-αP、IL-1 和 IL-6 水平显著升高（P<0.01）。持续性和永久性 AF 患者的血清炎症细胞因子水平高于阵发性 AF 患者；所有 AF 患者的血清水平均高于对照组（P<0.05）。使用多元逻辑回归分析，我们发现 SAA（OR 3.11；95% CI，1.12-6.05）、hsCRP（OR 2.53；95% CI，1.17-4.38）、TNF-α（OR 1.80；95% CI，1.03-3.20）和 IL-6（OR 1.21；95% CI，0.68-2.87）与 AF 相关（P<0.05）。AF 患者的 SAA 和相关炎症细胞因子升高。本研究首次证明 AF 患者的 SAA 升高。尽管 AF 患者 SAA 水平升高的原因尚不清楚，但升高的 SAA 可能反映了促进 AF 发生和持续的炎症状态。
