荧光标记的磁性纳米粒子用于通过磁共振对聚合酶链反应进行高灵敏度监测。
Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance.
机构信息
Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Charlestown, 02129, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6904-7. doi: 10.1002/anie.201201661. Epub 2012 Jun 8.
Abstract
Easy to find: magnetic nanoparticles bearing fluorochromes (red) that intercalate with DNA (green) form microaggregates with DNA generated by the polymerase chain reaction (PCR). These aggregates can be detected at low cycle numbers by magnetic resonance (MR).
摘要
易于发现
带有荧光染料（红色）的磁性纳米颗粒与聚合酶链反应（PCR）产生的 DNA（绿色）进行插入反应，形成与 DNA 微聚集。这些聚集体可以通过磁共振（MR）在低循环数下检测到。
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