Department of Infectious Diseases, The 3rd Affiliated Hospital, Sun Yat-Sen University, No.600, Tianhe Road, Guangzhou 510630, China.
J Infect. 2012 Oct;65(4):336-42. doi: 10.1016/j.jinf.2012.05.009. Epub 2012 Jun 8.
The role of interleukin-32 (IL-32) in chronic hepatitis B (CHB) remains unclear. In order to identify the role of IL-32 in CHB, we detected the expression levels of IL-32 in liver samples of CHB patients and analyzed the correlation between IL-32 and liver inflammation/fibrosis.
Real-time PCR and immunohistochemistry were used to detect the expression levels of IL-32 in liver tissues of patients with CHB. The correlation between hepatic IL-32 expression and the severity of liver inflammation/fibrosis was assessed using Spearman's correlation.
Hepatic IL-32 expression was increased in CHB patients and increased with the severity of liver inflammation/fibrosis. Moreover, hepatic IL-32 expression was significantly positively correlated with serum ALT level and negatively related with serum ALB level.
Our results suggest that IL-32 could be implicated in HBV-related liver inflammation/fibrosis. We believe that IL-32 might play important roles in the pathogenesis of CHB.
白细胞介素 32（IL-32）在慢性乙型肝炎（CHB）中的作用尚不清楚。为了确定 IL-32 在 CHB 中的作用，我们检测了 CHB 患者肝组织中 IL-32 的表达水平，并分析了 IL-32 与肝炎症/纤维化之间的相关性。
采用实时 PCR 和免疫组织化学法检测 CHB 患者肝组织中 IL-32 的表达水平。采用 Spearman 相关分析评估肝内 IL-32 表达与肝炎症/纤维化严重程度的相关性。
CHB 患者肝内 IL-32 表达增加，且随着肝炎症/纤维化的严重程度增加而增加。此外，肝内 IL-32 表达与血清 ALT 水平呈显著正相关，与血清 ALB 水平呈负相关。
我们的结果表明，IL-32 可能参与了 HBV 相关的肝炎症/纤维化。我们认为，IL-32 可能在 CHB 的发病机制中发挥重要作用。
