利用刺激诱发的内在光学信号对视网膜光感受器和内层神经元进行功能成像。
Functional imaging of retinal photoreceptors and inner neurons using stimulus-evoked intrinsic optical signals.
作者信息
Yao Xin-Cheng, Li Yi-Chao
机构信息
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Methods Mol Biol. 2012;884:277-85. doi: 10.1007/978-1-61779-848-1_20.
Abstract
Retinal development is a dynamic process both anatomically and functionally. High-resolution imaging and dynamic monitoring of photoreceptors and inner neurons can provide important information regarding the structure and function of the developing retina. In this chapter, we describe intrinsic optical signal (IOS) imaging as a high spatiotemporal resolution method for functional study of living retinal tissues. IOS imaging is based on near infrared (NIR) light detection of stimulus-evoked transient change of inherent optical characteristics of the cells. With no requirement for exogenous biomarkers, IOS imaging is totally noninvasive for functional mapping of stimulus-evoked spatiotemporal dynamics of the photoreceptors and inner retinal neurons.
摘要
视网膜发育在解剖学和功能上都是一个动态过程。对光感受器和内层神经元进行高分辨率成像和动态监测，可以提供有关发育中视网膜结构和功能的重要信息。在本章中，我们将固有光学信号（IOS）成像描述为一种用于活体视网膜组织功能研究的高时空分辨率方法。IOS成像基于对细胞固有光学特性的刺激诱发瞬态变化进行近红外（NIR）光检测。由于不需要外源性生物标志物，IOS成像对于光感受器和视网膜内层神经元刺激诱发的时空动力学功能映射完全是非侵入性的。
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