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本文引用的文献

1
In vivo functional retinal optical coherence tomography.活体视网膜功能光学相干断层扫描。
J Biomed Opt. 2010 Jul-Aug;15(4):041513. doi: 10.1117/1.3463008.
2
Parallel optical monitoring of visual signal propagation from the photoreceptors to the inner retina layers.从光感受器到内视网膜层的视觉信号传播的并行光学监测。
Opt Lett. 2010 Jun 1;35(11):1810-2. doi: 10.1364/OL.35.001810.
3
High-speed line-scan confocal imaging of stimulus-evoked intrinsic optical signals in the retina.高速线扫描共焦成像刺激诱发的视网膜内固有光学信号。
Opt Lett. 2010 Feb 1;35(3):426-8. doi: 10.1364/OL.35.000426.
4
Variable optical activation of human cone photoreceptors visualized using a short coherence light source.利用短相干光源可视化人眼锥状光感受器的变光学激活。
Opt Lett. 2009 Dec 15;34(24):3782-4. doi: 10.1364/OL.34.003782.
5
In vivo functional imaging of human cone photoreceptors.人类视锥光感受器的体内功能成像。
Opt Express. 2007;15(4):16141-16160. doi: 10.1364/OE.15.016141.
6
Stimulus-evoked intrinsic optical signals in the retina: spatial and temporal characteristics.视网膜中刺激诱发的内在光学信号：空间和时间特征。
Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4865-72. doi: 10.1167/iovs.08-3290. Epub 2009 May 6.
7
Optical dissection of stimulus-evoked retinal activation.刺激诱发视网膜激活的光学剖析
Opt Express. 2008 Aug 18;16(17):12446-59. doi: 10.1364/oe.16.012446.
8
Intrinsic signals from human cone photoreceptors.来自人类视锥光感受器的内在信号。
Invest Ophthalmol Vis Sci. 2008 Feb;49(2):713-9. doi: 10.1167/iovs.07-0837.
9
Optical imaging to evaluate retinal activation by electrical currents using suprachoroidal-transretinal stimulation.利用脉络膜上腔-视网膜刺激通过光学成像评估电流对视网膜的激活作用。
Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4777-84. doi: 10.1167/iovs.07-0209.
10
Intrinsic signal imaging in macaque retina reveals different types of flash-induced light reflectance changes of different origins.猕猴视网膜的内在信号成像揭示了不同起源的不同类型的闪光诱导光反射变化。
Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2903-12. doi: 10.1167/iovs.06-1294.

微透镜阵列记录局部视网膜反应。

Microlens array recording of localized retinal responses.

机构信息

Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

出版信息

Opt Lett. 2010 Nov 15;35(22):3838-40. doi: 10.1364/OL.35.003838.

DOI:10.1364/OL.35.003838
PMID:21082014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3001029/
Abstract

We designed a rapid functional imager for the parallel recording of localized intrinsic optical signals (IOSs). This imager used a microlens array (MLA)-based illuminator to deliver visible stimulus light and near-infrared (NIR) recording light simultaneously. The parfocal configuration of the stimulus and recording light illumination enabled confocal recording of the stimulus-evoked IOSs. Because the MLA stimulation/recording spots were widely separated on the retina, and only the photoreceptors within the MLA stimulation/recording spots were stimulated, the potential IOS cross talk effect among neighboring retinal areas was minimized. Our experiments revealed robust IOS activities tightly correlated with localized retinal responses.

摘要

我们设计了一种用于并行记录局部固有光学信号（IOSs）的快速功能成像仪。该成像仪使用基于微透镜阵列（MLA）的照明器同时传输可见刺激光和近红外（NIR）记录光。刺激光和记录光照明的共焦配置实现了对刺激引起的 IOS 的共焦记录。由于 MLA 刺激/记录点在视网膜上广泛分离，并且只有在 MLA 刺激/记录点内的光感受器受到刺激，因此相邻视网膜区域之间的潜在 IOS 串扰效应最小化。我们的实验揭示了与局部视网膜反应紧密相关的强大 IOS 活动。