Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, 3000 DR Rotterdam, The Netherlands.
Hum Reprod. 2012 Aug;27(8):2365-72. doi: 10.1093/humrep/des177. Epub 2012 Jun 12.
The incidence of overweight and obesity in men of reproductive ages is rising, which may affect fertility. Therefore, this study aims to assess the associations between BMI, central adiposity and sperm parameters in men of subfertile couples.
Ejaculate volume (ml), sperm concentration (millions per ml), percentage of progressive motile and immotile spermatozoa and total motile sperm count (millions) were measured in 450 men of subfertile couples visiting a tertiary outpatient clinic for reproductive treatment and preconception counseling.
Overweight was negatively associated with the percentage of progressive motility type A [β -0.32 (SE 0.2), P=0.036] and positively associated with the percentage of immotility type C [β 0.21 (SE 0.07), P=0.002]. Obesity was negatively associated with ejaculate volume [β-0.23 (SE 0.1), P=0.02], sperm concentration [β -0.77 (SE 0.3), P=0.006] and total motile sperm count [β -0.91 (SE 0.3), P=0.007]. Waist circumference≥102 cm, a measure for central adiposity, was inversely associated with sperm concentration [β -0.69 (SE 0.2), P=0.001] and total motile sperm count [β-0.62 (SE 0.3), P=0.02]. All associations remained significant after adjustment for age, ethnicity, active and passive smoking, alcohol and medication use and folate status.
This study shows that in particular, sperm concentration and total motile sperm count in men of subfertile couples are detrimentally affected by a high BMI and central adiposity. The effect of weight loss on sperm quality and fertility needs further investigation.
处于生育年龄的男性超重和肥胖的发病率正在上升，这可能会影响生育能力。因此，本研究旨在评估肥胖指数（BMI）、中心性肥胖与生育能力低下男性的精子参数之间的关系。
在一家三级门诊诊所，对 450 名生育能力低下的男性进行了精液量（毫升）、精子浓度（每毫升百万）、前向运动精子（A 级）比例、非前向运动精子（C 级）比例和总前向运动精子计数（百万）的测量，这些男性均接受了生殖治疗和孕前咨询。
超重与 A 级前向运动精子的比例呈负相关（β-0.32 [SE 0.2]，P=0.036），与 C 级非前向运动精子的比例呈正相关（β 0.21 [SE 0.07]，P=0.002）。肥胖与精液量呈负相关（β-0.23 [SE 0.1]，P=0.02），与精子浓度呈负相关（β-0.77 [SE 0.3]，P=0.006），与总前向运动精子计数呈负相关（β-0.91 [SE 0.3]，P=0.007）。腰围≥102cm，即中心性肥胖的衡量标准，与精子浓度呈负相关（β-0.69 [SE 0.2]，P=0.001），与总前向运动精子计数呈负相关（β-0.62 [SE 0.3]，P=0.02）。所有关联在调整年龄、种族、主动和被动吸烟、酒精和药物使用以及叶酸状态后仍然显著。
本研究表明，特别是生育能力低下男性的精子浓度和总前向运动精子计数受到 BMI 和中心性肥胖的不利影响。体重减轻对精子质量和生育能力的影响需要进一步研究。
