维吾尔药异常黑胆质成熟剂对S180和艾氏腹水癌小鼠肿瘤模型的抗肿瘤及抗氧化活性的影响。
The impact of the Uighur medicine abnormal savda munziq on antitumor and antioxidant activity in a S180 and Ehrlich ascites carcinoma mouse tumor model.
作者信息
Aikemu Ainiwaer, Yusup Abdiryim, Umar Anwar, Berké Bénédicte, Moore Nicholas, Upur Halmurat
机构信息
Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, Xinjiang People's Republic of China.
出版信息
Pharmacogn Mag. 2012 Apr;8(30):141-8. doi: 10.4103/0973-1296.96568.
AIM
This study was designed to study the antitumor and antioxidant activity of Uighur medicine abnormal savda munziq (ASMq) in the S180 and Ehrlich ascites carcinoma mice tumor model.
MATERIALS AND METHODS
The serum levels of superoxide dismutase (SOD), malonaldehyde (MDA), and glutathione-catalase (GSH-PX) were analyzed, and the mice were also subjected to a hypoxia tolerance test. Their climbing ability was also analyzed.
RESULTS
The findings of the study revealed that ASMq-treatment leads to an increase in blood serum SOD and GSH-PX levels but a decrease in blood serum MDA levels. Moreover, ASMq-treatment enhanced the survival time of mice maintained under hypoxic conditions and improved their mice climbing ability.
CONCLUSIONS
The results of this study indicate that ASMq has obvious antitumor and antioxidative effects.
目的
本研究旨在研究维吾尔药异常黑胆质成熟剂（ASMq）在S180和艾氏腹水癌小鼠肿瘤模型中的抗肿瘤和抗氧化活性。
材料与方法
分析血清中超氧化物歧化酶（SOD）、丙二醛（MDA）和谷胱甘肽过氧化物酶（GSH-PX）的水平，并对小鼠进行耐缺氧试验。同时分析其攀爬能力。
结果
研究结果显示，ASMq治疗可导致血清SOD和GSH-PX水平升高，但血清MDA水平降低。此外，ASMq治疗可延长缺氧条件下小鼠的存活时间，并提高其攀爬能力。
结论
本研究结果表明，ASMq具有明显的抗肿瘤和抗氧化作用。
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