Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia.
BMC Pediatr. 2012 Jun 15;12:73. doi: 10.1186/1471-2431-12-73.
The aim of this study was to validate a model for optimal birth weight derived from neonatal records, and to test the assumption that preterm births may be considered optimally grown if they are not exposed to common factors that perturb fetal growth.
Weights of fetuses were estimated from serial biometric ultrasound scans (N = 2,848) and combined with neonatal weights for a prospective pregnancy cohort (N = 691). Non-Caucasians, fetuses subsequently born preterm and those with diagnosed or suspected determinants of aberrant growth were excluded leaving fetuses assumed to have experienced normal growth. A generalised linear longitudinal growth model for optimal weight was derived, including terms for gestational duration, infant sex, maternal height and birth order. This model was compared to a published model derived solely from birth weights.
Prior to 30 weeks gestation, the published model yielded systematically lower weights than the model derived from both fetal weight and neonatal weight. From 30 weeks gestation the two models were indistinguishable.
The model for optimal birth weight was valid for births that have attained at least 30 weeks gestation. The model derived from both fetal and neonatal weights is recommended prior to this gestation.
本研究旨在验证从新生儿记录中得出的最佳出生体重模型，并检验以下假设，即如果早产儿不受干扰胎儿生长的常见因素影响，则可视为最佳生长。
我们从连续的超声生物测量扫描中估算了胎儿的体重（N=2848），并将其与前瞻性妊娠队列的新生儿体重相结合（N=691）。非白种人、随后早产的胎儿以及有诊断或疑似生长异常决定因素的胎儿被排除在外，假设这些胎儿经历了正常的生长。得出了一个适用于最佳体重的广义线性纵向生长模型，其中包括胎龄、婴儿性别、母亲身高和出生顺序等术语。将该模型与仅从出生体重得出的已发表模型进行了比较。
在 30 周妊娠之前，与从胎儿体重和新生儿体重得出的模型相比，发表的模型得出的体重系统偏低。从 30 周妊娠开始，这两个模型无法区分。
适用于至少达到 30 周妊娠的出生体重的模型是有效的。建议在这一妊娠之前使用从胎儿和新生儿体重得出的模型。
