铱催化 C-H 硼化的外层空间指向。
Outer-sphere direction in iridium C-H borylation.
机构信息
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-1322, USA.
出版信息
J Am Chem Soc. 2012 Jul 18;134(28):11350-3. doi: 10.1021/ja303443m. Epub 2012 Jul 3.
Abstract
The NHBoc group affords ortho selective C-H borylations in arenes and alkenes. Experimental and computational studies support an outer sphere mechanism where the N-H proton hydrogen bonds to a boryl ligand oxygen. The regioselectivities are unique and complement those of directed ortho metalations.
摘要
NHBoc 基团可在芳烃和烯烃中实现邻位选择性 C-H 硼化。实验和计算研究支持一种外球机理，其中 N-H 质子与硼基配体氧形成氢键。该反应的区域选择性是独特的，可以与导向的邻位金属化反应互补。
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