Department of Public Health and Primary Health Care and Centre of Pharmacy, University of Bergen, P.O. Box 7804, 5020 Bergen, Norway.
Eur J Clin Pharmacol. 2013 Feb;69(2):269-77. doi: 10.1007/s00228-012-1331-5. Epub 2012 Jun 17.
The objective of the study was to examine the safety of ginger use during pregnancy on congenital malformations and selected pregnancy outcomes.
The Norwegian Mother and Child Cohort study, a large population-based cohort, provided the data used in this study. Our study population consisted of 68,522 women. Data on ginger use and socio-demographic factors were retrieved from three self-administered questionnaires completed by the women during weeks 17 and 30 of the pregnancy and when their child was 6 months old. Data on pregnancy outcomes were provided by the Medical Birth Registry of Norway.
Among the 68,522 women in the study, 1,020 (1.5 %) women reported using ginger during pregnancy. The use of ginger during pregnancy was not associated with any increased risk of congenital malformations. No increased risk for stillbirth/perinatal death, preterm birth, low birth weight, or low Apgar score was detected for the women exposed to ginger during pregnancy compared to women who had not been exposed.
Use of ginger during pregnancy does not seem to increase the risk of congenital malformations, stillbirth/perinatal death, preterm birth, low birth weight, or low Apgar score. This finding is clinically important for health care professionals giving advice to pregnant women with NPV.
本研究旨在探讨妊娠期使用生姜的安全性，包括对先天性畸形和某些特定妊娠结局的影响。
本研究的数据来自于挪威母婴队列研究，该研究是一项大型基于人群的队列研究。我们的研究人群包括 68522 名女性。在妊娠第 17 周到 30 周以及婴儿 6 个月大时，通过三次由女性自行填写的调查问卷收集了她们关于生姜使用情况和社会人口学因素的数据，同时还从挪威医学出生登记处获取了妊娠结局的数据。
在 68522 名研究女性中，有 1020 名（1.5%）女性报告在妊娠期间使用了生姜。与未使用生姜的女性相比，妊娠期使用生姜与先天性畸形的风险增加无关。与未使用生姜的女性相比，妊娠期使用生姜与死产/围产儿死亡、早产、低出生体重或低 Apgar 评分之间没有显著关联。
妊娠期使用生姜似乎不会增加先天性畸形、死产/围产儿死亡、早产、低出生体重或低 Apgar 评分的风险。这一发现对于向有自然流产史的孕妇提供建议的医疗保健专业人员具有重要的临床意义。
